Ontology highlight
ABSTRACT:
SUBMITTER: Pishchany G
PROVIDER: S-EPMC4038968 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Pishchany Gleb G Sheldon Jessica R JR Dickson Claire F CF Alam Md Tauqeer MT Read Timothy D TD Gell David A DA Heinrichs David E DE Skaar Eric P EP
The Journal of infectious diseases 20131213 11
Staphylococcus aureus is a Gram-positive pathogen responsible for tremendous morbidity and mortality. As with most bacteria, S. aureus requires iron to cause disease, and it can acquire iron from host hemoglobin. The current model for staphylococcal hemoglobin-iron acquisition proposes that S. aureus binds hemoglobin through the surface-exposed hemoglobin receptor IsdB. IsdB removes heme from bound hemoglobin and transfers this cofactor to other proteins of the Isd system, which import and degra ...[more]