Biglycan enhances gastric cancer invasion by activating FAK signaling pathway.
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ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC4039113 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Biglycan enhances gastric cancer invasion by activating FAK signaling pathway.
Hu Lei L Duan Yan-Tao YT Li Jian-Fang JF Su Li-Ping LP Yan Min M Zhu Zheng-Gang ZG Liu Bing-Ya BY Yang Qiu-Meng QM
Oncotarget 20140401 7
Biglycan (BGN) is an important member of small leucine-rich proteoglycans family, and has been implicated in oncogenesis and development of various human cancer types. Here we report that BGN promotes tumor invasion and metastasis of gastric cancer both in vitro and in vivo. BGN expression is significantly higher in gastric cancer tissues and associated with lymph node metastasis, depth of tumor invasion and TNM stage. BGN enhances gastric cancer cell wound healing, migration and invasion abilit ...[more]
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