Ontology highlight
ABSTRACT:
SUBMITTER: Borsi E
PROVIDER: S-EPMC4039126 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Borsi Enrica E Perrone Giulia G Terragna Carolina C Martello Marina M Dico Angela F AF Solaini Giancarlo G Baracca Alessandra A Sgarbi Gianluca G Pasquinelli Gianandrea G Valente Sabrina S Zamagni Elena E Tacchetti Paola P Martinelli Giovanni G Cavo Michele M
Oncotarget 20140401 7
The increasing importance of hypoxia-inducible factor-1α (HIF-1α) in tumorigenesis raises the possibility that agents which specifically inhibit this transcription factor, would provide significant therapeutic benefit. The constitutive expression of HIF-1α in about 35% of Multiple Myeloma (MM) patients suggests HIF-1α suppression might be part of a therapeutic strategy. Accordingly, we explored the effect of EZN-2968, a small 3rd generation antisense oligonucleotide against HIF-1α, in a panel of ...[more]