Ontology highlight
ABSTRACT:
SUBMITTER: Monti P
PROVIDER: S-EPMC4039150 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Monti Paola P Ciribilli Yari Y Bisio Alessandra A Foggetti Giorgia G Raimondi Ivan I Campomenosi Paola P Menichini Paola P Fronza Gilberto G Inga Alberto A
Oncotarget 20140401 8
TP63 is a member of the TP53 gene family that encodes for up to ten different TA and ∆N isoforms through alternative promoter usage and alternative splicing. Besides being a master regulator of gene expression for squamous epithelial proliferation, differentiation and maintenance, P63, through differential expression of its isoforms, plays important roles in tumorigenesis. All P63 isoforms share an immunoglobulin-like folded DNA binding domain responsible for binding to sequence-specific respons ...[more]