The genetic landscape of anaplastic astrocytoma.
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ABSTRACT:
SUBMITTER: Killela PJ
PROVIDER: S-EPMC4039223 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
The genetic landscape of anaplastic astrocytoma.
Killela Patrick J PJ Pirozzi Christopher J CJ Reitman Zachary J ZJ Jones Sian S Rasheed B Ahmed BA Lipp Eric E Friedman Henry H Friedman Allan H AH He Yiping Y McLendon Roger E RE Bigner Darell D DD Yan Hai H
Oncotarget 20140301 6
Anaplastic astrocytoma WHO grade III (A3) is a lethal brain tumor that often occurs in middle aged patients. Clinically, it is challenging to distinguish A3 from glioblastoma multiforme (GBM) WHO grade IV. To reveal the genetic landscape of this tumor type, we sequenced the exome of a cohort of A3s (n=16). For comparison and to illuminate the genomic landscape of other glioma subtypes, we also included in our study diffuse astrocytoma WHO grade II (A2, n=7), oligoastrocytoma WHO grade II (OA2, n ...[more]
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