Ontology highlight
ABSTRACT:
SUBMITTER: Assefnia S
PROVIDER: S-EPMC4039224 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Oncotarget 20140301 6
Cadherin-11 (CDH11), associated with epithelial to mesenchymal transformation in development, poor prognosis malignancies and cancer stem cells, is also a major therapeutic target in rheumatoid arthritis (RA). CDH11 expressing basal-like breast carcinomas and other CDH11 expressing malignancies exhibit poor prognosis. We show that CDH11 is increased early in breast cancer and ductal carcinoma in-situ. CDH11 knockdown and antibodies effective in RA slowed the growth of basal-like breast tumors an ...[more]