Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC4039345 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Wang Liang L Han Yujing Y Zhou Shuo S Wang Guihua G Guan Xiyun X
ACS applied materials & interfaces 20140514 10
We report a label-free real-time nanopore sensing method for the detection of anthrax lethal factor, a component of the anthrax toxin, by using a complementary single-stranded DNA as a molecular probe. The method is rapid and sensitive: sub-nanomolar concentrations of the target anthrax lethal factor DNA could be detected in ∼1 min. Further, our method is selective, which can differentiate the target DNA from other single-stranded DNA molecules at the single-base resolution. This sequence-specif ...[more]