Ontology highlight
ABSTRACT:
SUBMITTER: Song C
PROVIDER: S-EPMC4039375 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Song Carl C Chiasson Melissa A MA Nursimulu Nirvana N Hung Stacy S SS Wasmuth James J Grigg Michael E ME Parkinson John J
Molecular systems biology 20131119
Increasingly, metabolic potential is proving to be a critical determinant governing a pathogen's virulence as well as its capacity to expand its host range. To understand the potential contribution of metabolism to strain-specific infectivity differences, we present a constraint-based metabolic model of the opportunistic parasite, Toxoplasma gondii. Dominated by three clonal strains (Type I, II, and III demonstrating distinct virulence profiles), T. gondii exhibits a remarkably broad host range. ...[more]