Ontology highlight
ABSTRACT:
SUBMITTER: Iacobucci GJ
PROVIDER: S-EPMC4039462 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Iacobucci Gary J GJ Rahman Noura Abdel NA Valtueña Aida Andrades AA Nayak Tapan Kumar TK Nayak Tapan Kumar TK Gunawardena Shermali S
PloS one 20140530 5
Efficient intracellular transport is essential for healthy cellular function and structural integrity, and problems in this pathway can lead to neuronal cell death and disease. To spatially and temporally evaluate how transport defects are initiated, we adapted a primary neuronal culture system from Drosophila larval brains to visualize the movement dynamics of several cargos/organelles along a 90 micron axonal neurite over time. All six vesicles/organelles imaged showed robust bi-directional mo ...[more]