Ontology highlight
ABSTRACT:
SUBMITTER: Gopal AK
PROVIDER: S-EPMC4039496 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Gopal Ajay K AK Kahl Brad S BS de Vos Sven S Wagner-Johnston Nina D ND Schuster Stephen J SJ Jurczak Wojciech J WJ Flinn Ian W IW Flowers Christopher R CR Martin Peter P Viardot Andreas A Blum Kristie A KA Goy Andre H AH Davies Andrew J AJ Zinzani Pier Luigi PL Dreyling Martin M Johnson Dave D Miller Langdon L LL Holes Leanne L Li Daniel D Dansey Roger D RD Godfrey Wayne R WR Salles Gilles A GA
The New England journal of medicine 20140122 11
<h4>Background</h4>Phosphatidylinositol-3-kinase delta (PI3Kδ) mediates B-cell receptor signaling and microenvironmental support signals that promote the growth and survival of malignant B lymphocytes. In a phase 1 study, idelalisib, an orally active selective PI3Kδ inhibitor, showed antitumor activity in patients with previously treated indolent non-Hodgkin's lymphomas.<h4>Methods</h4>In this single-group, open-label, phase 2 study, 125 patients with indolent non-Hodgkin's lymphomas who had not ...[more]