Ontology highlight
ABSTRACT:
SUBMITTER: Manganas LN
PROVIDER: S-EPMC4039561 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Manganas Louis N LN Zhang Xueying X Li Yao Y Hazel Raphael D RD Smith S David SD Wagshul Mark E ME Henn Fritz F Benveniste Helene H Djuric Petar M PM Enikolopov Grigori G Maletic-Savatic Mirjana M
Science (New York, N.Y.) 20071101 5852
The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentratio ...[more]