Ontology highlight
ABSTRACT:
SUBMITTER: Gauthier-Campbell C
PROVIDER: S-EPMC404016 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Gauthier-Campbell Catherine C Bredt David S DS Murphy Timothy H TH El-Husseini Alaa El-Din Ael-D
Molecular biology of the cell 20040220 5
Although neuronal axons and dendrites with their associated filopodia and spines exhibit a profound cell polarity, the mechanism by which they develop is largely unknown. Here, we demonstrate that specific palmitoylated protein motifs, characterized by two adjacent cysteines and nearby basic residues, are sufficient to induce filopodial extensions in heterologous cells and to increase the number of filopodia and the branching of dendrites and axons in neurons. Such motifs are present at the N-te ...[more]