Ontology highlight
ABSTRACT:
SUBMITTER: Jung HY
PROVIDER: S-EPMC4040269 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20130919 2
Fine control of Wnt signaling is essential for various cellular and developmental decision-making processes. However, deregulation of Wnt signaling leads to pathological consequences, one of which is cancer. Here, we identify a function of PAF, a component of translesion DNA synthesis, in modulating Wnt signaling. PAF is specifically overexpressed in colon cancer cells and intestinal stem cells and is required for colon cancer cell proliferation. In Xenopus laevis, ventrovegetal expression of PA ...[more]