Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-? responses in tumor-associated macrophages.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4040301 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Fatty acid-binding protein E-FABP restricts tumor growth by promoting IFN-β responses in tumor-associated macrophages.
Zhang Yuwen Y Sun Yanwen Y Rao Enyu E Yan Fei F Li Qiang Q Zhang Ying Y Silverstein Kevin A T KA Liu Shujun S Sauter Edward E Cleary Margot P MP Li Bing B
Cancer research 20140408 11
Fatty acid-binding proteins (FABP) are known central regulators of both metabolic and inflammatory pathways, but their role in tumor development remains largely unexplored. Here, we report that host expression of epidermal FABP (E-FABP) protects against mammary tumor growth. We find that E-FABP is highly expressed in macrophages, particularly in a specific subset, promoting their antitumor activity. In the tumor stroma, E-FABP-expressing tumor-associated macrophages (TAM) produce high levels of ...[more]
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