Ontology highlight
ABSTRACT:
SUBMITTER: Cighetti R
PROVIDER: S-EPMC4040397 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20131212 2
Monosaccharide lipid A mimetics based on a glucosamine core linked to two fatty acid chains and bearing one or two phosphate groups have been synthesized. Compounds 1 and 2, each with one phosphate group, were practically inactive in inhibiting LPS-induced TLR4 signaling and cytokine production in HEK-blue cells and murine macrophages, but compound 3, with two phosphate groups, was found to be active in efficiently inhibiting TLR4 signal in both cell types. The direct interaction between compoun ...[more]