Ontology highlight
ABSTRACT:
SUBMITTER: Bieghs V
PROVIDER: S-EPMC4040540 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Bieghs Veerle V Walenbergh Sofie M A SM Hendrikx Tim T van Gorp Patrick J PJ Verheyen Fons F Olde Damink Steven W SW Masclee Ad A AA Koek Ger H GH Hofker Marten H MH Binder Christoph J CJ Shiri-Sverdlov Ronit R
Liver international : official journal of the International Association for the Study of the Liver 20130425 7
<h4>Background & aims</h4>Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and inflammation. The transition from steatosis towards NASH represents a key step in pathogenesis, as it will set the stage for further severe liver damage. Under normal conditions, lipoproteins that are endocytosed by Kupffer cells (KCs) are easily transferred from the lysosomes into the cytoplasm. Oxidized LDL (oxLDL) that is taken up by the macrophages in vitro is trapped within the lysosomes, while ...[more]