Ontology highlight
ABSTRACT:
SUBMITTER: He B
PROVIDER: S-EPMC4040567 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
He Bing B Chen Changya C Teng Li L Tan Kai K
Proceedings of the National Academy of Sciences of the United States of America 20140512 21
Enhancer mapping has been greatly facilitated by various genomic marks associated with it. However, little is available in our toolbox to link enhancers with their target promoters, hampering mechanistic understanding of enhancer-promoter (EP) interaction. We develop and characterize multiple genomic features for distinguishing true EP pairs from noninteracting pairs. We integrate these features into a probabilistic predictor for EP interactions. Multiple validation experiments demonstrate a sig ...[more]