Ontology highlight
ABSTRACT:
SUBMITTER: Kailasan Vanaja S
PROVIDER: S-EPMC4040571 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Kailasan Vanaja Sivapriya S Rathinam Vijay A K VA Atianand Maninjay K MK Kalantari Parisa P Skehan Brian B Fitzgerald Katherine A KA Leong John M JM
Proceedings of the National Academy of Sciences of the United States of America 20140514 21
Enterohemorrhagic Escherichia coli (EHEC) is an extracellular pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome. The proinflammatory cytokine, interleukin-1β, has been linked to hemolytic uremic syndrome. Here we identify the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome as an essential mediator of EHEC-induced IL-1β. Whereas EHEC-specific virulence factors were dispensable for NLRP3 activation, bacterial ...[more]