Ontology highlight
ABSTRACT:
SUBMITTER: Shand FH
PROVIDER: S-EPMC4040600 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Shand Francis H W FH Ueha Satoshi S Otsuji Mikiya M Koid Suang Suang SS Shichino Shigeyuki S Tsukui Tatsuya T Kosugi-Kanaya Mizuha M Abe Jun J Tomura Michio M Ziogas James J Matsushima Kouji K
Proceedings of the National Academy of Sciences of the United States of America 20140513 21
Myeloid cells such as monocytes and monocyte-derived macrophages promote tumor progression. Recent reports suggest that extramedullary hematopoiesis sustains a sizable reservoir of tumor-infiltrating monocytes in the spleen. However, the influence of the spleen on tumor development and the extent to which spleen monocytes populate the tumor relative to bone marrow (BM) monocytes remain controversial. Here, we used mice expressing the photoconvertible protein Kikume Green-Red to track the redistr ...[more]