Ontology highlight
ABSTRACT:
SUBMITTER: Rieger KE
PROVIDER: S-EPMC404097 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Rieger Kerri E KE Hong Wan-Jen WJ Tusher Virginia Goss VG Tang Jean J Tibshirani Robert R Chu Gilbert G
Proceedings of the National Academy of Sciences of the United States of America 20040419 17
Toxicity from radiation therapy is a grave problem for cancer patients. We hypothesized that some cases of toxicity are associated with abnormal transcriptional responses to radiation. We used microarrays to measure responses to ionizing and UV radiation in lymphoblastoid cells derived from 14 patients with acute radiation toxicity. The analysis used heterogeneity-associated transformation of the data to account for a clinical outcome arising from more than one underlying cause. To compute the r ...[more]