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Acellular biomaterials: an evolving alternative to cell-based therapies.

ABSTRACT: Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.

SUBMITTER: Burdick JA

PROVIDER: S-EPMC4041107 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Acellular biomaterials: an evolving alternative to cell-based therapies.

Burdick Jason A JA Mauck Robert L RL Gorman Joseph H JH Gorman Robert C RC

Science translational medicine 20130301 176

Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurr ...[more]

PMID: 23486777

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