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Genome-wide meta-analysis identifies new susceptibility loci for migraine.

ABSTRACT: Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

SUBMITTER: Anttila V 

PROVIDER: S-EPMC4041123 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Anttila Verneri V   Winsvold Bendik S BS   Gormley Padhraig P   Kurth Tobias T   Bettella Francesco F   McMahon George G   Kallela Mikko M   Malik Rainer R   de Vries Boukje B   Terwindt Gisela G   Medland Sarah E SE   Todt Unda U   McArdle Wendy L WL   Quaye Lydia L   Koiranen Markku M   Ikram M Arfan MA   Lehtimäki Terho T   Stam Anine H AH   Ligthart Lannie L   Wedenoja Juho J   Dunham Ian I   Neale Benjamin M BM   Palta Priit P   Hamalainen Eija E   Schürks Markus M   Rose Lynda M LM   Buring Julie E JE   Ridker Paul M PM   Steinberg Stacy S   Stefansson Hreinn H   Jakobsson Finnbogi F   Lawlor Debbie A DA   Evans David M DM   Ring Susan M SM   Färkkilä Markus M   Artto Ville V   Kaunisto Mari A MA   Freilinger Tobias T   Schoenen Jean J   Frants Rune R RR   Pelzer Nadine N   Weller Claudia M CM   Zielman Ronald R   Heath Andrew C AC   Madden Pamela A F PAF   Montgomery Grant W GW   Martin Nicholas G NG   Borck Guntram G   Göbel Hartmut H   Heinze Axel A   Heinze-Kuhn Katja K   Williams Frances M K FMK   Hartikainen Anna-Liisa AL   Pouta Anneli A   van den Ende Joyce J   Uitterlinden Andre G AG   Hofman Albert A   Amin Najaf N   Hottenga Jouke-Jan JJ   Vink Jacqueline M JM   Heikkilä Kauko K   Alexander Michael M   Muller-Myhsok Bertram B   Schreiber Stefan S   Meitinger Thomas T   Wichmann Heinz Erich HE   Aromaa Arpo A   Eriksson Johan G JG   Traynor Bryan B   Trabzuni Daniah D   Rossin Elizabeth E   Lage Kasper K   Jacobs Suzanne B R SBR   Jacobs Suzanne B R SBR   Gibbs J Raphael JR   Birney Ewan E   Kaprio Jaakko J   Penninx Brenda W BW   Boomsma Dorret I DI   van Duijn Cornelia C   van Duijn Cornelia C   Raitakari Olli O   Jarvelin Marjo-Riitta MR   Zwart John-Anker JA   Cherkas Lynn L   Strachan David P DP   Kubisch Christian C   Ferrari Michel D MD   van den Maagdenberg Arn M J M AMJM   Dichgans Martin M   Wessman Maija M   Smith George Davey GD   Stefansson Kari K   Daly Mark J MJ   Nyholt Dale R DR   Chasman Daniel D   Palotie Aarno A  

Nature genetics 20130623 8

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C  ...[more]

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