Measuring similarity between dynamic ensembles of biomolecules.
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ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC4041546 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Measuring similarity between dynamic ensembles of biomolecules.
Yang Shan S Salmon Loïc L Al-Hashimi Hashim M HM
Nature methods 20140406 5
We present a simple and general approach termed REsemble for quantifying population overlap and structural similarity between ensembles. This approach captures improvements in the quality of ensembles determined using increasing input experimental data--improvements that go undetected when conventional methods for comparing ensembles are used--and reveals unexpected similarities between RNA ensembles determined using NMR and molecular dynamics simulations. ...[more]
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