Recognizing methylated histone variant H3.3 to prevent tumors.
Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesh S
PROVIDER: S-EPMC4042173 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Recognizing methylated histone variant H3.3 to prevent tumors.
Venkatesh Swaminathan S Workman Jerry L JL
Cell research 20140415 6
Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription regulation in suppressing tumors. ...[more]
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