Ontology highlight
ABSTRACT:
SUBMITTER: Vagenas P
PROVIDER: S-EPMC4042403 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Vagenas Panagiotis P Di Paola Angela A Herme Maua M Lincoln Thomas T Skiest Daniel J DJ Altice Frederick L FL Springer Sandra A SA
Journal of substance abuse treatment 20140312 1
Extended-release naltrexone (XR-NTX), an approved treatment for opioid or alcohol dependence, is a once-monthly injectable formulation of naltrexone. Hepatotoxicity concerns have limited its use, necessitating further investigation. This study aims to examine hepatic enzyme levels in participants of 2 randomized placebo-controlled trials (RCTs) of XR-NTX. Hepatic transaminases were measured in 85 patients enrolled in RCTs of XR-NTX among HIV-infected prisoners, transitioning to the community and ...[more]