Ontology highlight
ABSTRACT:
SUBMITTER: Mizuno R
PROVIDER: S-EPMC4042632 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Mizuno Rei R Kamioka Yuji Y Kabashima Kenji K Imajo Masamichi M Sumiyama Kenta K Nakasho Eiji E Ito Takeshi T Hamazaki Yoko Y Okuchi Yoshihisa Y Sakai Yoshiharu Y Kiyokawa Etsuko E Matsuda Michiyuki M
The Journal of experimental medicine 20140519 6
Many chemical mediators regulate neutrophil recruitment to inflammatory sites. Although the actions of each chemical mediator have been demonstrated with neutrophils in vitro, how such chemical mediators act cooperatively or counteractively in vivo remains largely unknown. Here, by in vivo two-photon excitation microscopy with transgenic mice expressing biosensors based on Förster resonance energy transfer, we time-lapse-imaged the activities of extracellular signal-regulated kinase (ERK) and pr ...[more]