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Improving oral human papillomavirus detection using toothbrush sampling in HIV-positive men who have sex with men.

ABSTRACT: Pre- and postabrasion oral rinse samples (ORS) and a toothbrush sample detected human papillomavirus (HPV) DNA in at least one sample among 45 (26%) of 173 HIV-positive men who have sex with men. There was moderate agreement for HPV genotype detection between the preabrasion and postabrasion ORS (? = 0.49; 95% confidence interval [CI], 0.37 to 0.61). There was good agreement between postabrasion ORS and toothbrushes (? = 0.70; 95% CI, 0.60 to 0.80). The sensitivities for HPV genotypes detected were 80% (95% CI, 69 to 88) for preabrasion ORS, 65% (95% CI, 54 to 76) for postabrasion ORS, and 75% (95% CI, 63 to 84) for toothbrushes.

SUBMITTER: Ong JJ

PROVIDER: S-EPMC4042741 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Improving oral human papillomavirus detection using toothbrush sampling in HIV-positive men who have sex with men.

Ong Jason J JJ Read Tim T Chen Marcus M Walker Sandra S Law Matthew M Bradshaw Catriona C Garland Suzanne M SM Tabrizi Sepehr N SN Cornall Alyssa A Grulich Andrew A Hocking Jane J Fairley Christopher K CK

Journal of clinical microbiology 20140409 6

Pre- and postabrasion oral rinse samples (ORS) and a toothbrush sample detected human papillomavirus (HPV) DNA in at least one sample among 45 (26%) of 173 HIV-positive men who have sex with men. There was moderate agreement for HPV genotype detection between the preabrasion and postabrasion ORS (κ = 0.49; 95% confidence interval [CI], 0.37 to 0.61). There was good agreement between postabrasion ORS and toothbrushes (κ = 0.70; 95% CI, 0.60 to 0.80). The sensitivities for HPV genotypes detected w ...[more]

PMID: 24719435

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