Ontology highlight
ABSTRACT:
SUBMITTER: Caccamo A
PROVIDER: S-EPMC4044255 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Caccamo Antonella A De Pinto Vito V Messina Angela A Branca Caterina C Oddo Salvatore S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140601 23
Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD. However, whether hyperactive mTOR plays a role in the cognitive deficits associated with AD remains elusive. Here, we genetically reduced mTOR signaling in the brains of Tg2576 mice, a widely used animal model of AD. We found that suppression of mTOR signaling reduced amyloid-β deposits and rescued memory deficits. Mechani ...[more]