Ontology highlight
ABSTRACT:
SUBMITTER: Jan M
PROVIDER: S-EPMC4045621 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Jan Max M Snyder Thomas M TM Corces-Zimmerman M Ryan MR Vyas Paresh P Weissman Irving L IL Quake Stephen R SR Majeti Ravindra R
Science translational medicine 20120801 149
Given that most bone marrow cells are short-lived, the accumulation of multiple leukemogenic mutations in a single clonal lineage has been difficult to explain. We propose that serial acquisition of mutations occurs in self-renewing hematopoietic stem cells (HSCs). We investigated this model through genomic analysis of HSCs from six patients with de novo acute myeloid leukemia (AML). Using exome sequencing, we identified mutations present in individual AML patients harboring the FLT3-ITD (intern ...[more]