Ontology highlight
ABSTRACT:
SUBMITTER: Blasic JR
PROVIDER: S-EPMC4045631 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Blasic Joseph R JR Lane Brown R R Robinson Phyllis R PR
Cellular and molecular life sciences : CMLS 20111213 9
Melanopsin-based phototransduction is involved in non-image forming light responses including circadian entrainment, pupil constriction, suppression of pineal melatonin synthesis, and direct photic regulation of sleep in vertebrates. Given that the functions of melanopsin involve the measurement and summation of total environmental luminance, there would appear to be no need for the rapid deactivation typical of other G-protein coupled receptors. In this study, however, we demonstrate that heter ...[more]