Ontology highlight
ABSTRACT:
SUBMITTER: Fuqua BK
PROVIDER: S-EPMC4045767 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Fuqua Brie K BK Lu Yan Y Darshan Deepak D Frazer David M DM Wilkins Sarah J SJ Wolkow Natalie N Bell Austin G AG Hsu JoAnn J Yu Catherine C CC Chen Huijun H Dunaief Joshua L JL Anderson Gregory J GJ Vulpe Chris D CD
PloS one 20140604 6
Hephaestin is a vertebrate multicopper ferroxidase important for the transfer of dietary iron from intestinal cells to the blood. Hephaestin is mutated in the sex-linked anemia mouse, resulting in iron deficiency. However, sex-linked anemia mice still retain some hephaestin ferroxidase activity. They survive, breed, and their anemia improves with age. To gain a better understanding of the role of hephaestin in iron homeostasis, we used the Cre-lox system to generate knockout mouse models with wh ...[more]