Ontology highlight
ABSTRACT:
SUBMITTER: Clark GW
PROVIDER: S-EPMC4046016 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Clark Greg W GW Ackerman Sharon H SH Tillier Elisabeth R ER Gatti Domenico L DL
BMC bioinformatics 20140522
<h4>Background</h4>Several methods are available for the detection of covarying positions from a multiple sequence alignment (MSA). If the MSA contains a large number of sequences, information about the proximities between residues derived from covariation maps can be sufficient to predict a protein fold. However, in many cases the structure is already known, and information on the covarying positions can be valuable to understand the protein mechanism and dynamic properties.<h4>Results</h4>In t ...[more]