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Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.

ABSTRACT: Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identification of novel genetic regulators.

SUBMITTER: Bramwell KK

PROVIDER: S-EPMC4046100 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.

Bramwell Kenneth K C KK Teuscher Cory C Weis Janis J JJ

Frontiers in cellular and infection microbiology 20140605

Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identif ...[more]

PMID: 24926442

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