Ontology highlight
ABSTRACT:
SUBMITTER: Bernal AJ
PROVIDER: S-EPMC4046115 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Bernal Autumn J AJ Dolinoy Dana C DC Huang Dale D Skaar David A DA Weinhouse Caren C Jirtle Randy L RL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121101 2
Humans are exposed to low-dose ionizing radiation (LDIR) from a number of environmental and medical sources. In addition to inducing genetic mutations, there is concern that LDIR may also alter the epigenome. Such heritable effects early in life can either be positively adaptive or result in the enhanced formation of diseases, including cancer, diabetes, and obesity. Herein, we show that LDIR significantly increased DNA methylation at the viable yellow agouti (A(vy)) locus in a sex-specific mann ...[more]