Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler MA
PROVIDER: S-EPMC4046273 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Wheeler Michael A MA Heffner Danielle L DL Kim Suemin S Espy Sarah M SM Spano Anthony J AJ Cleland Corey L CL Deppmann Christopher D CD
Neuron 20140501 3
Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are unknown. We have identified tumor necrosis factor (TNF) receptor 1 (TNFR1) as a critical modifier of TrkA and Ret signaling in peptidergic and nonpeptidergic nociceptors. Specifically ...[more]