Netrins and Wnts function redundantly to regulate antero-posterior and dorso-ventral guidance in C. elegans.

ABSTRACT: Guided migrations of cells and developing axons along the dorso-ventral (D/V) and antero-posterior (A/P) body axes govern tissue patterning and neuronal connections. In C. elegans, as in vertebrates, D/V and A/P graded distributions of UNC-6/Netrin and Wnts, respectively, provide instructive polarity information to guide cells and axons migrating along these axes. By means of a comprehensive genetic analysis, we found that simultaneous loss of Wnt and Netrin signaling components reveals previously unknown and unexpected redundant roles for Wnt and Netrin signaling pathways in both D/V and A/P guidance of migrating cells and axons in C. elegans, as well as in processes essential for organ function and viability. Thus, in addition to providing polarity information for migration along the axi

SUBMITTER: Levy-Strumpf N 

PROVIDER: S-EPMC4046927 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature