Using HIV networks to inform real time prevention interventions.

ABSTRACT:

Objective

To reconstruct the local HIV-1 transmission network from 1996 to 2011 and use network data to evaluate and guide efforts to interrupt transmission.

Design

HIV-1 pol sequence data were analyzed to infer the local transmission network.

Methods

We analyzed HIV-1 pol sequence data to infer a partial local transmission network among 478 recently HIV-1 infected persons and 170 of their sexual and social contacts in San Diego, California. A transmission network score (TNS) was developed to estimate the risk of HIV transmission from a newly diagnosed individual to a new partner and target prevention interventions.

Results

HIV-1 pol sequences from 339 individuals (52.3%) were highly similar to sequences from at least one other participant (i.e., clustered). A

SUBMITTER: Little SJ 

PROVIDER: S-EPMC4047027 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature