Ontology highlight
ABSTRACT:
SUBMITTER: Valapala M
PROVIDER: S-EPMC4047365 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Valapala Mallika M Maji Sayantan S Borejdo Julian J Vishwanatha Jamboor K JK
The Journal of biological chemistry 20140417 23
Glutamate-induced elevation in intracellular Ca(2+) has been implicated in excitotoxic cell death. Neurons respond to increased glutamate levels by activating an extracellular proteolytic cascade involving the components of the plasmin-plasminogen system. AnxA2 is a Ca(2+)-dependent phospholipid binding protein and serves as an extracellular proteolytic center by recruiting the tissue plasminogen activator and plasminogen and mediating the localized generation of plasmin. Ratiometric Ca(2+) imag ...[more]