Ontology highlight
ABSTRACT:
SUBMITTER: Sunryd JC
PROVIDER: S-EPMC4047382 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Sunryd Johan C JC Cheon Banyoon B Graham Jill B JB Giorda Kristina M KM Fissore Rafael A RA Hebert Daniel N DN
The Journal of biological chemistry 20140424 23
The endoplasmic reticulum (ER) is organized in part by adapter proteins that nucleate the formation of large protein complexes. Tetratricopeptide repeats (TPR) are well studied protein structural motifs that support intermolecular protein-protein interactions. TMTC1 and TMTC2 were identified by an in silico search as TPR-containing proteins possessing N-terminal ER targeting signal sequences and multiple hydrophobic segments, suggestive of polytopic membrane proteins that are targeted to the sec ...[more]