Ontology highlight
ABSTRACT:
SUBMITTER: Hresko RC
PROVIDER: S-EPMC4047383 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20140404 23
Pharmacologic HIV protease inhibitors (PIs) and structurally related oligopeptides are known to reversibly bind and inactivate the insulin-responsive facilitative glucose transporter 4 (GLUT4). Several PIs exhibit isoform selectivity with little effect on GLUT1. The ability to target individual GLUT isoforms in an acute and reversible manner provides novel means both to investigate the contribution of individual GLUTs to health and disease and to develop targeted treatment of glucose-dependent d ...[more]