Ontology highlight
ABSTRACT:
SUBMITTER: Ridley C
PROVIDER: S-EPMC4047408 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Ridley Caroline C Kouvatsos Nikos N Raynal Bertrand D BD Howard Marj M Collins Richard F RF Desseyn Jean-Luc JL Jowitt Thomas A TA Baldock Clair C Davis C William CW Hardingham Timothy E TE Thornton David J DJ
The Journal of biological chemistry 20140428 23
Mucins are essential components in mucus gels that form protective barriers at all epithelial surfaces, but much remains unknown about their assembly, intragranular organization, and post-secretion unfurling to form mucus. MUC5B is a major polymeric mucin expressed by respiratory epithelia, and we investigated the molecular mechanisms involved during its assembly. Studies of intact polymeric MUC5B revealed a single high affinity calcium-binding site, distinct from multiple low affinity sites on ...[more]