Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex.
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ABSTRACT:
SUBMITTER: Vermeer PD
PROVIDER: S-EPMC4048035 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Targeting ERBB receptors shifts their partners and triggers persistent ERK signaling through a novel ERBB/EFNB1 complex.
Vermeer Paola D PD Colbert Paul L PL Wieking Bryant G BG Vermeer Daniel W DW Lee John H JH
Cancer research 20130628 18
Most squamous cell carcinomas of the head and neck (HNSCC) overexpress ERBB1/EGFR, but EGF receptor (EGFR)-targeted therapies have yielded disappointing clinical results in treatment of this cancer. Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylation and downstream signaling persists in the presence of cetuximab. Mechanistically, cetuximab drives a shift in EGFR dimerization partners within the signaling complex, suggesting t ...[more]
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