Ontology highlight
ABSTRACT:
SUBMITTER: Bosch Calero C
PROVIDER: S-EPMC4048348 | biostudies-literature | 2014 Jan-Feb
REPOSITORIES: biostudies-literature
Bosch Calero Cristina C Selga Elisabet E Brugada Ramon R Scornik Fabiana S FS Pérez Guillermo J GJ
Channels (Austin, Tex.) 20131203 1
Large-conductance Ca(2+)-activated (BK) channels, expressed in a variety of tissues, play a fundamental role in regulating and maintaining arterial tone. We recently demonstrated that the slow voltage indicator DiBAC4(3) does not depend, as initially proposed, on the β 1 or β 4 subunits to activate native arterial smooth muscle BK channels. Using recombinant mslo BK channels, we now show that the β 1 subunit is not essential to this activation but exerts a large potentiating effect. DiBAC4(3) pr ...[more]