High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.
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ABSTRACT:
SUBMITTER: Slaughter J
PROVIDER: S-EPMC4048710 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
High correlations in gene expression between paired umbilical cord blood and neonatal blood of healthy newborns on Guthrie cards.
Slaughter Jaime J Wei Changshuai C Korzeniewski Steven J SJ Lu Qing Q Beck John S JS Khoo Sok Kean SK Brovont Ariel A Maurer Joel J Martin Denny D Lenski Madeleine M Paneth Nigel N
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20130724 18
<h4>Objective</h4>To examine the correlation in genes expressed in paired umbilical cord blood (UCB) and newborn blood (NB).<h4>Method</h4>Total mRNA and mRNA of three gene sets (inflammatory, hypoxia, and thyroidal response) was assessed using microarray in UCB and NB spotted on Guthrie cards from 7 mother/infant pairs.<h4>Results</h4>The average gene expression correlation between paired UCB and NB samples was 0.941 when all expressed genes were considered, and 0.949 for three selected gene se ...[more]
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