Ontology highlight
ABSTRACT:
SUBMITTER: Chappell CP
PROVIDER: S-EPMC4048786 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Chappell Craig P CP Giltiay Natalia V NV Draves Kevin E KE Chen ChangHung C Hayden-Ledbetter Martha S MS Shlomchik Mark J MJ Kaplan Daniel H DH Clark Edward A EA
Journal of immunology (Baltimore, Md. : 1950) 20140514 12
The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is expressed exclusively on human plasmacytoid DCs (pDCs) and plays a role in Ag capture, internalization, and presentation to T cells. We used transgenic mice that express human BDCA2 and anti-BDCA2 mAbs to deliver Ags directly to BDCA2 on pDCs in vivo. Targeting Ag to pDCs in this manner resulted in significant suppression of Ag-specific CD4(+) T cell and Ab responses upon secondary exposure to Ag in the presence of adjuvant. Suppres ...[more]