Ontology highlight
ABSTRACT:
SUBMITTER: Mizuguchi M
PROVIDER: S-EPMC4048911 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mizuguchi Mineyuki M Fuju Takahiro T Obita Takayuki T Ishikawa Mitsuru M Tsuda Masaaki M Tabuchi Akiko A
Scientific reports 20140609
The megakaryoblastic leukemia 1 (MKL1) protein functions as a transcriptional coactivator of the serum response factor. MKL1 has three RPEL motifs (RPEL1, RPEL2, and RPEL3) in its N-terminal region. MKL1 binds to monomeric G-actin through RPEL motifs, and the dissociation of MKL1 from G-actin promotes the translocation of MKL1 to the nucleus. Although structural data are available for RPEL motifs of MKL1 in complex with G-actin, the structural characteristics of RPEL motifs in the free state hav ...[more]