Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.
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ABSTRACT:
SUBMITTER: Chowdhury G
PROVIDER: S-EPMC4048925 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.
Chowdhury Goutam G Cho Sung-Hee SH Pegg Anthony E AE Guengerich F Peter FP
Angewandte Chemie (International ed. in English) 20131015 49
A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O(6) -alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis. ...[more]
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