Ontology highlight
ABSTRACT:
SUBMITTER: Chong CR
PROVIDER: S-EPMC4049336 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Chong Curtis R CR Jänne Pasi A PA
Nature medicine 20131107 11
All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually develop resistance. An increasing understanding of the number and complexity of resistance mechanisms highlights the Herculean challenge of killing tumors that are resistant to EGFR inhibitors. Our growing knowledge of resistance pathways provides an opportunity to develop new mechanism-based inhibitors and combination ...[more]