Ontology highlight
ABSTRACT:
SUBMITTER: Butali A
PROVIDER: S-EPMC4049366 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Butali Azeez A Mossey Peter A PA Adeyemo Wasiu L WL Eshete Mekonen A MA Gaines LauRen A LA Even Dee D Braimah Ramat O RO Aregbesola Babatunde S BS Rigdon Jennifer V JV Emeka Christian I CI James Olutayo O Ogunlewe Mobolanle O MO Ladeinde Akinola L AL Abate Fikre F Hailu Taye T Mohammed Ibrahim I Gravem Paul E PE Deribew Milliard M Gesses Mulualem M Adeyemo Adebowale A AA Murray Jeffrey C JC
Molecular genetics & genomic medicine 20140127 3
Orofacial clefts (OFC) are complex genetic traits that are often classified as syndromic or nonsyndromic clefts. Currently, there are over 500 types of syndromic clefts in the Online Mendelian Inheritance in Man (OMIM) database, of which Van der Woude syndrome (VWS) is one of the most common (accounting for 2% of all OFC). Popliteal pterygium syndrome (PPS) is considered to be a more severe form of VWS. Mutations in the IRF6 gene have been reported worldwide to cause VWS and PPS. Here, we report ...[more]