Dataset Information

Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women.

Study design

We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using random effects models.

Results

Twenty-two studies (n?=?33,405) were selected. Fasting insulin levels were not different between women with and without breast cancer (standardized mean difference, SMD -0.03, 95%CI -0.32 to 0.27; p?=?0.9). Similarly, non-fasting/fasting C-peptide levels were not different between the two groups (mean difference, MD 0.07, -0.21 to 0.34; p?=?0.6). Using individual odds ratios (ORs) adjusted at least for age, there was no higher risk of breast cancer when upper quartiles were compared with the lowest quartile (Q1) of fasting insulin levels (OR Q2 vs. Q1 0.96, 0.71 to 1.28; OR Q3 vs. Q1 1.22, 0.91 to 1.64; OR Q4 vs. Q1 0.98, 0.70 to 1.38). Likewise, there were no differences for quartiles of non-fasting/fasting C-peptide levels (OR Q2 vs. Q1 1.12, 0.91 to 1.37; OR Q3 vs. Q1 1.20, 0.91 to 1.59; OR Q4 vs. Q1 1.40, 1.03 to 1.92). Homeostatic model assessment (HOMA-IR) levels in breast cancer patients were significantly higher than in people without breast cancer (MD 0.22, 0.13 to 0.31, p<0.00001).

Conclusions

Higher levels of fasting insulin or non-fasting/fasting C-peptide are not associated with breast cancer in women. HOMA-IR levels are slightly higher in women with breast cancer.

SUBMITTER: Hernandez AV

PROVIDER: S-EPMC4049776 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis.

Hernandez Adrian V AV Guarnizo Mirella M Miranda Yony Y Pasupuleti Vinay V Deshpande Abhishek A Paico Socorro S Lenti Hosten H Ganoza Silvia S Montalvo Laritza L Thota Priyaleela P Lazaro Herbert H

PloS one 20140609 6

<h4>Objective</h4>This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women.<h4>Study design</h4>We conducted a systematic review of four databases (PubMed-Medline, EMBASE, Web of Science, and Scopus) for observational studies evaluating components defining insulin resistance in women with and without breast cancer. A meta-analysis of the association between insulin resistance components and breast cancer was performed using r ...[more]

PMID: 24911052

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Dataset Information

Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis.

Objective

Study design

Results

Conclusions

Publications

Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis.

Similar Datasets

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